Subinhibitory Concentrations of LFF571 Reduce Toxin Production by Clostridium difficile
نویسندگان
چکیده
منابع مشابه
Sub - inhibitory concentrations of LFF 571 reduce toxin production by 1 Clostridium difficile
17 LFF571 is a novel semi-synthetic thiopeptide antibacterial that is undergoing investigation for 18 safety and efficacy in patients with moderate C. difficile infections. LFF571 inhibits bacterial 19 protein synthesis by interacting with elongation factor Tu (EF-Tu) and interrupting complex 20 formation between EF-Tu and aminoacyl-tRNA. Given this mechanism of action, we 21 hypothesized that ...
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It is known that the major etiologic agent of pseudomembranous colitis in man is Clostridium difficile. With respect to traditional use of almond paste in the treatment of infantile diarrhea, we studied the effects of the aqueous extract of Amygdalus communis (AEAC) on the growth and toxin production of Clostridium difficile in culture medium and the rabbit ligated ileal loop. Three groups...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.04436-14